Course Objectives:
Students will acquire knowledge about sampling and their handling and preparation and results calculation and data reporting. In addition they will learn and develop understanding about the classical techniques of analytical chemistry and quality control and quality assurance
Course Contents:
Chemometrics:
Sampling, significant figures, stoichiometric calculations, measurement errors, analysis of variance (ANOVA), arithmetic mean, median, mode, standard deviation/relative standard deviation, confidence limits, Gaussian distribution, least square method, tests for significance, outliers
Quality Control and Quality Assurance:
Definitions, seven tools for quality control, the concept of quality assurance, quality assurance techniques, validations based on design qualification (DQ), installation qualification (IQ), operational qualification (OQ) and performance qualification (PQ), calibrations, monitoring and quality reviews, periodical trainings, six sigma concept, ISO standards.
Classical Analytical Methods:
Acid-base, complexometric and redox titrations, gravimetric analysis.
CHEM-111 Lab.
Calibration of volumetric glassware, electronic and analytical equipment, statistical evaluation of analytical data including linear regression analysis, constructing a calibration curve from a given analytical data using spread sheet software, determination of hardness of water using EDTA, determination of chloride in tap water sample, estimation of copper, arsenic, hydrogen peroxide and vitamin C using iodometry, gravimetric analysis, determination of barium in barium nitrate, determination of nickel in a given steel sample, determination of bicarbonates in a clinical sample using back-titration, determination of cation in a mixture by complexometric titration, studying the effect of common ions on solubility of sparingly soluble salts (e. g. AgCl / PbSO4).